Endocrine Abstracts

Background: PCOS is characterized from chronic anovulation, clinically expressed as menstrual irregularities, hyperandrogenism and polycystic ovaries on ultrasound. A growing body of data indicates that PCOS is a life existing disease starting before puberty and lasting post menopause, as hormonal and metabolic changes exist through the life span of the patient. Since the presence of menstrual irregularities constitutes a prerequisite for the diagnosis of PCOS, we wonder if th...

Serum levels of soluble RAGE (sRAGE total), the soluble isoform of the receptor of advanced glycated end products (AGEs) that lacks the transmembrane and intracytoplasmic domains of RAGE, has been found elevated in type 2 diabetics and non diabetic subjects and positively correlated with AGEs levels. In women with PCOS, while serum AGEs have been demonstrated to be elevated, sRAGE levels have not been determined as yet.The aim of the present study was to...

In female rats, diet enriched in advanced glycation end products (AGEs) has been associated with increased serum testosterone levels and deposition of dietary glycotoxins in ovarian tissue.Women with PCOS present increased serum AGE levels, which are acutely elevated after intake of a single meal high in AGE content. In this study the effects of a hypocaloric diet and an AGE-enriched hypocaloric diet were investigated, on the endocrine and metabolic prof...